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Mitochondria are microscopic, energy producing machines that are found in all human cells. Mitochondria are essential for the normal function and survival of all eukaryotic cells. Mitochondria contain a small set of genes that must work properly to make the energy our bodies require for health. Given their central role in providing energy for cells it is not surprising that mitochondrial dysfunction is involved in neurodegenerative disorders, diabetes, and cancer. Despite their importance the regulation of gene expression in mammalian mitochondria remains poorly understood. Defects in the expression of mitochondrial genes cause debilitating diseases for which there are no cures currently.

Our team investigates RNA-binding proteins that regulate the stability, expression and translation of mitochondrial genes. We investigate the genetic causes of diseases caused by mitochondrial dysfunction and analyse the molecular mechanisms that cause pathology in the diseases. As well as unravelling the mysteries of mitochondrial genetics and biology we are interested in the development of gene therapy approaches and therapeutics to combat mitochondrial dysfunction in disease.

Professor Aleksandra Filipovska

Professor Aleksandra Filipovska

Mitochondrial Medicine and Biology

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Scientists find way to wipe a cell’s memory to better reprogram it as a stem cell

In a groundbreaking study published today in Nature, Australian scientists have resolved a long-standing problem in regenerative medicine. Led by Professor Ryan Lister from the Harry Perkins Institute of Medical Research and The University of Western Australia and Professor Jose M Polo from Monash University and the University of Adelaide,…

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Perkins researcher elected as prestigious new Fellow

Professor Alistair Forrest from the Harry Perkins Institute of Medical Research has been selected alongside 27 new Fellows of the Australian Academy of Health and Medical Sciences. Professor Forrest is internationally regarded for his pioneering work, which has been driving forward our understanding of human diseases and the complex behaviour…

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Molecular machines stop cancer’s clock

Head of the laboratory for Synthetic Biology and Drug Discovery, Professor Oliver Rackham, says cancer cells grow uncontrollably whereas normal cells limit their growth. “A normal cell grows for just the right amount of time that is required for us to develop and maintain our bodies. “They control their growth with…

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