Home  >  Research  >  Labs  >  Cancer Program  >  LABORATORY FOR CANCER MEDICINE

RESEARCH OVERVIEW

The Laboratory for Cancer Medicine team is driving a program of research that aims to discover new ways of treating cancer. The initial focus was on hormone dependent cancers, such as breast and prostate, but in recent years has expanded to include other cancers which may be associated with a poor prognosis – liver, colon, melanoma and head and neck. Our goal is to discover ways to abrogate the key pathways driving the growth of these tumors, with a view to translating some of these discoveries into new therapies.

From the mechanistic point of view, we have had a long-term interest in RNA biology and human disease, and this has led to discoveries of novel RNA-binding proteins that are involved in regulating hormone action in breast and prostate cancer. One of these, SLIRP, is a repressor of nuclear receptor hormone action that we are exploring in the context of prostate and colon cancer. Several other novel regulators of hormone action have been identified (eg. PACT), which are being investigated using genome-wide approaches in the context of their role as activators of prostate cancer growth.

Our interest in RNA biology was a natural fit for developing significant focus in microRNAs and cancer. microRNAs are short non-coding RNAs that play central roles in regulating normal cell growth. They offer great promise in cancer biology, as they present new avenues for diagnostics and therapeutics. Our studies have resulted in the discovery of several “tumor suppressor microRNAs” that suppress key signalling pathways in poor prognostic tumors, such as head and neck, melanoma and liver cancer. One of these, microRNA-7 or miR-7, acts a potent suppressor of cancer cell proliferation and invasion by targeting the EGF-receptor (EGFR) pathway. In parallel with our work to explore the functional biology of miR-7 in EGFR-driven tumors (head and neck, liver, prostate, glioma) using genome-wide approaches and preclinical models, we have established a spin-out company, miReven, which is focused on developing miR-7 as a potential ‘miR replacement therapy” for these cancers which we hope to move into early phase clinical trials in the forthcoming years. 

LATEST NEWS

Cancer researcher inspired by nature to kill cancer

A WA discovery made global news when venom from honeybees was found to kill aggressive breast cancer cells. Associate Professor and Wesfarmers Fellow, Dr Pilar Blancafort, from the Harry Perkins Institute of Medical Research, co-published these findings with her PhD student Dr Ciara Duffy and laboratory co-workers a few months…

Read More

Big ideas pay off for West Australian researchers

Harry Perkins Institute of Medical Research recognised by Federal Government for innovative research projects Detection of illicit drugs, novel cancer research, fighting infections in rapid time and hunting for rare muscle weakening disease genes are some of WA’s research areas that have been awarded National Health and Medical Research Council…

Read More
Lisa_Nilsson-Jonas_Nilsson

Your help brings international experts to Perth

If you’re ever facing a devastating disease diagnosis, you’ll want the best medical care possible and access to the best scientific minds in your home State, working with local doctors and researchers to push forward improved outcomes for patients like you. Now, thanks to your ongoing support, a world expert…

Read More

I'M LOOKING FOR

RESEARCH PROJECTS

TEAM MEMBERS

PUBLICATIONS