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RESEARCH OVERVIEW

We are interested in the cancer microenvironment or tumour stroma which consists of various cell types, including immune cells and blood vessels, and supports cancer growth. Our research program aims to understand how stromal cells are remodelled, and the extent to which stromal networks regulate cancer progression. We have shown that the tumour microenvironment is highly dynamic and can be re-programmed or remodelled to enhance immune cell uptake and overall response to immunotherapy. Furthermore, we have developed precision tools to specifically target abnormal stromal features to disrupt and re-program signalling networks between multiple stromal components and to break the vicious cycle of disease progression and relapse.

Utilising a suite of preclinical cancer models which includes genetically modified mouse models of pancreatic cancers, orthotopic cancer models of breast, lung, brain and melanoma, and human cancer specimens our goal is to develop new drugs that can increase the survival rate and quality of life of cancer patients.

Professor Ruth Ganss

Professor Ruth Ganss

Cancer Microenvironment

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LATEST NEWS

Artists impression of the Perkins' WA Comprehensive Cancer Centre

Cancer researchers welcome Federal funding for WA centre

Western Australian cancer sufferers to receive patient centred care linked to research. Fast facts: Cancer is a major cause of death by disease in adults and children in Australia More than 145,000 Australians were diagnosed with cancer in 2020 In 2020 nearly 50,000 Australians died from cancer Deaths from cancer…

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Perkins Researchers Rebooting Evolution

The building blocks of life-saving therapeutics could be developed in days instead of years thanks to new software that simulates evolution. Proseeker is the name of a new computational tool that mimics the processes of natural selection, producing proteins that can be used for a range of medicinal and household…

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WA joins national call to improve cancer outcomes

Fast Facts Cancer is a leading cause of death by disease in adults and children in Australia More than 145,000 Australians were diagnosed with cancer in 2020 In 2020 nearly 50,000 Australians died from cancer Cancer was the leading cause of death for children aged 1–14 between 2015– 2017 Cancer…

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