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RESEARCH OVERVIEW

We are interested in the cancer microenvironment or tumour stroma which consists of various cell types, including immune cells and blood vessels, and supports cancer growth. Our research program aims to understand how stromal cells are remodelled, and the extent to which stromal networks regulate cancer progression. We have shown that the tumour microenvironment is highly dynamic and can be re-programmed or remodelled to enhance immune cell uptake and overall response to immunotherapy. Furthermore, we have developed precision tools to specifically target abnormal stromal features to disrupt and re-program signalling networks between multiple stromal components and to break the vicious cycle of disease progression and relapse.

Utilising a suite of preclinical cancer models which includes genetically modified mouse models of pancreatic cancers, orthotopic cancer models of breast, lung, brain and melanoma, and human cancer specimens our goal is to develop new drugs that can increase the survival rate and quality of life of cancer patients.

Professor Ruth Ganss

Professor Ruth Ganss

Cancer Microenvironment

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LATEST NEWS

New treatment discovery for rare eye cancer

An unusual and often fatal form of eye melanoma shows early response to new combination of treatments. New discoveries in treatments are all about improved health outcomes for people who have diseases like cancer, and providing them with more time with families.   Thanks to the ongoing support of donors…

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Walking for new cancer treatments for 1 in 7 women

More than $1 million raised in the 2021 Walk for Women's Cancer, and counting! – 775 Walkers deliver for medical research                    More than 770 women and men stepped out from Perth’s Harry Perkins Institute of Medical Research at 7am on Saturday 29 May in the Walk for Women’s Cancer…

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Why walk 35kms when you could walk 70?

Breast cancer survivor pushes herself to say thank you Four years clear of cancer, Connie Nicoletti-Lewins is committed to supporting the people who work to solve cancer’s mysteries and develop new treatments. Inspired by Perth’s annual Walk for Women’s Cancer that raises funds for cancer researchers at the Harry Perkins…

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