Home  >  Research  >  Labs  >  Cancer Program  >  CANCER MICROENVIRONMENT

RESEARCH OVERVIEW

We are interested in the cancer microenvironment or tumour stroma which consists of various cell types, including immune cells and blood vessels, and supports cancer growth. Our research program aims to understand how stromal cells are remodelled, and the extent to which stromal networks regulate cancer progression. We have shown that the tumour microenvironment is highly dynamic and can be re-programmed or remodelled to enhance immune cell uptake and overall response to immunotherapy. Furthermore, we have developed precision tools to specifically target abnormal stromal features to disrupt and re-program signalling networks between multiple stromal components and to break the vicious cycle of disease progression and relapse.

Utilising a suite of preclinical cancer models which includes genetically modified mouse models of pancreatic cancers, orthotopic cancer models of breast, lung, brain and melanoma, and human cancer specimens our goal is to develop new drugs that can increase the survival rate and quality of life of cancer patients.

Professor Ruth Ganss

Professor Ruth Ganss

Cancer Microenvironment

Read more

LATEST NEWS

Perkins secures biobanking grants to answer important questions in future research

The McGowan Government recently announced that the Harry Perkins Institute will receive two of the 16 grants totalling more than $1.5 million to support Western Australian biobanks. Congratulations to both Professor Grant Morahan who is Head of the Perkins' Centre for Diabetes Research, and Dr Louise Winteringham who leads the…

Read More

NHMRC funding for DEFINER to identify “the right drug for the right patient” in liver cancer

The Harry Perkins Institute's Oncofetal Ecosystem Laboratory, established early in 2021, has received its first NHMRC Ideas Grant in the most recent grants round. This collaborative project run by the Perkins and Curtin University will investigate a new immunotherapy treatment for the most common type of primary liver cancer, hepatocellular…

Read More

Bioengineers deliver innovation award success

Combining engineering thinking with medical research has proved a winning formula for four Perth start-up companies linked to the Harry Perkins Institute of Medical Research in Nedlands. They were winners in the State government’s WA Innovator of the Year (WAIOTY) awards and recipients of grants from the MTPConnect WA Life…

Read More