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RESEARCH OVERVIEW

We are interested in the cancer microenvironment or tumour stroma which consists of various cell types, including immune cells and blood vessels, and supports cancer growth. Our research program aims to understand how stromal cells are remodelled, and the extent to which stromal networks regulate cancer progression. We have shown that the tumour microenvironment is highly dynamic and can be re-programmed or remodelled to enhance immune cell uptake and overall response to immunotherapy. Furthermore, we have developed precision tools to specifically target abnormal stromal features to disrupt and re-program signalling networks between multiple stromal components and to break the vicious cycle of disease progression and relapse.

Utilising a suite of preclinical cancer models which includes genetically modified mouse models of pancreatic cancers, orthotopic cancer models of breast, lung, brain and melanoma, and human cancer specimens our goal is to develop new drugs that can increase the survival rate and quality of life of cancer patients.

LATEST NEWS

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Your help brings international experts to Perth

If you’re ever facing a devastating disease diagnosis, you’ll want the best medical care possible and access to the best scientific minds in your home State, working with local doctors and researchers to push forward improved outcomes for patients like you. Now, thanks to your ongoing support, a world expert…

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Going bald to battle sarcoma

Perkins alumnus, Matthew Eton, is facing an important fight. In May this year, Matthew was diagnosed with synovial sarcoma – a subtype of the rare bone and connective tissue cancer - for the second time in five years. As a show of support while Matthew undergoes chemo, his partner Max…

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Boost for liver cancer patients with new $10.8 million world-class research centre

Patients with primary liver cancer will benefit from a new $10.8 million research centre established with a $5 million Cancer Research Trust grant and $5.8 million from Minderoo Foundation, Curtin University, The University of Western Australia, Harry Perkins Institute of Medical Research, the State Government and charitable organisations. Primary liver…

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