CURRENT RESEARCH PROJECTS
CURRENT STUDENT PROJECTS
Student Project
Relationship between fluid resuscitation and the endothelium in sepsis-associated coagulopathy
Student Project
Relationship between fluid resuscitation and the endothelium in sepsis-associated coagulopathy
Project Outline
To investigate how intravenous fluid resuscitation in sepsis affects the function of endothelial cells, in particular activation of the coagulation cascade and platelets. The approach will include in vitro experiments involving blood samples obtained from patients undergoing resuscitation for sepsis. The relationship between intravenous fluids, degradation of the endothelial glycocalyx and up-regulation of endothelial cell pathways involved in coagulation and platelet binding will be explored. These findings will be correlated with a range of clinical measures of coagulopathy.
Recommended reading
- Kaukonen K-M, et al. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand 2000-2012. JAMA 2014;311:1308-16
- Angus DC, van de Poll T. Severe Sepsis and Septic Shock. N Engl J Med 2013;369:840-51
- Deutschman CS, Tracey KJ. Sepsis: current dogma and new perspectives. Immunity 2014; 40(4): 463-75.
- Prucha M, Bellingan G, Zazula R. Sepsis biomarkers. Clin Chim Acta 2015; 440: 97-103.
- Biron BM, Ayala A, Lomas-Neira JL. Biomarkers for Sepsis: What Is and What Might Be? Biomark Insights 2015; 10(Suppl 4): 7-17.
Contact details: [email protected]; [email protected]
Chief supervisor
Professor Daniel Fatovich
Other supervisor
Assoc Prof Glenn Arendts, Dr Erika Bosio
Project suitable for
PhD
Essential qualifications
BSc (Hons) or equivalent, or Masters
Start date
2020
Student Project
Anaphylaxis and Snakebite: Mechanisms of activation of immune cells by antivenoms
Student Project
Anaphylaxis and Snakebite: Mechanisms of activation of immune cells by antivenoms
Project Outline
Understanding reactions to antivenom is essential for improving patient safety when antivenom is administered. These studies will help identify strategies to reduce the incidence of antivenom reactions and patients at risk who may benefit from closer monitoring or premedication, if shown to be effective.
Recommended reading
Kasturiratne A, et al. The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths. PLoSMed 2008; 5(11): e218.
Fox S, et al. Underestimation of snakebite mortality by hospital statistics in the Monaragala District of Sri Lanka. Transactions of the Royal Society of Tropical Medicine and Hygiene 2006; 100(7): 693-5.
Isbister GK, Bawaskar HS. Scorpion envenomation. N Engl J Med 2014; 371(5): 457-63.
Gutierrez JM, et al. Assessing the preclinical efficacy of antivenoms: from the lethality neutralization assay to antivenomics. Toxicon2013; 69: 168-79.
Contact details: [email protected]; [email protected]
Chief supervisor
Professor Daniel Fatovich
Other supervisor
Professor Simon Brown, Dr. Erika Bosio
Project suitable for
PhD
Essential qualifications
BSc (Hons) or equivalent, or Masters
Student Project
MicroRNAs as biomarkers for the diagnosis of critical illness
Student Project
MicroRNAs as biomarkers for the diagnosis of critical illness
Project Outline
Aims
- To investigate miRNA species present in different disease states.
- To identify candidate miRNA biomarkers present within specific patient cohorts.
- To validate these candidates with a view to developing a diagnostic test for use in the emergency department.
Recommended reading
- Wang J, Chen J, Sen S. MicroRNA as Biomarkers and Diagnostics. J Cell Physiol 2016; 231(1): 25-30.
- Bronze-da-Rocha E. MicroRNAs expression profiles in cardiovascular diseases. Biomed Res Int 2014; 2014: 985408.
- van Rooij E. The art of microRNA research. Circulation research 2011; 108(2): 219-34.
Contact details: [email protected]
Chief supervisor
Professor Daniel Fatovich
Other supervisor
Dr Erika Bosio, Assoc Prof Glenn Arendts
Project suitable for
PhD
Essential qualifications
BSc (Hons) or equivalent, or Masters
Student Project
Unravelling the association between delirium and attendance by older people from aged care to the emergency department
Student Project
Unravelling the association between delirium and attendance by older people from aged care to the emergency department
Project Outline
Our centre has conducted prior cluster randomised trials that revealed that preventative interventions in aged care improve quality of life for residents but do not reduce the rate of transfer to hospital from facilities. One clear reason was the development of acute delirium in residents went undetected until secondary morbidity (e.g poor oral intake with dehydration, injurious falls, challenging behaviour) had become established. The PhD student will use this information to trial early detection strategies in aged care facilities to enable better recognition and management of acute delirium residents at an earlier stage. The strategies will have a clinical focus with some opportunity for basic laboratory analysis. Results will build on quality of life gains for older people already achieved, as well as reduce distressing hospital transfer, morbidity and mortality.
- To investigate the point prevalence of delirium in people attending emergency from aged care facilities.
- To experimentally trial brief screening instruments to improve delirium detection in aged care.
- To validate the chosen instrument in a cluster randomised trial.
Recommended reading
- Hare M et al. Psychosomatics 2014;55:235-42
- Arendts G et al. Arch Gerontol Geriatr. 2014;58(1):15-19
Contact details: [email protected]
Chief supervisor
Assoc Prof Glenn Arendts
Other supervisor
Dr Erika Bosio, Assoc Prof Glenn Arendts
Project suitable for
PhD
Essential qualifications
BSc (Hons), BPsych (Hons) or equivalent, or Masters