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CURRENT RESEARCH PROJECTS

Project

Perkins Cancer Biobank

Project

Perkins Cancer Biobank

Project Outline

The Perkins Cancer Biobank collects, characterises and stores tumour samples. These biospecimens, together with high quality detailed biological, pharmacological and diagnostic data will provide an important resource to inform patient treatment and predict patient outcome.

Research area
Cancer

Laboratory
Translational Cancer Research Program

Contact
Louise Winteringham

Project

Growing 3D tumours in the laboratory

Project

Growing 3D tumours in the laboratory

Project Outline

We are growing patient-derived tumours in the laboratory. Patient-derived tumour organoids provide a more advanced laboratory model and are useful for screening multiple drugs/combinations of drugs to determine the best treatment options for individual patients.

In addition, we are growing tissue slice cultures which preserve the tumour cells within their surrounding environment. This allows us to study how the tumour microenvironment contributes to the response of the tumour cells to different treatments.

Research area
Cancer

Laboratory
Translational Cancer Research Program

Contact
Louise Winteringham

Project

Patient derived xenograft models

Project

Patient derived xenograft models

Project Outline

Currently more than 80% of oncology clinical trials will fail. One of the main reasons for this is that many laboratory models do not accurately represent cancer growth. We are developing patient derived xenograft models of various cancers. These pre-clinical models of real patient tumours allow us to undertake sophisticated pre-clinical trials for new drugs and new combination therapies. More accurate pre-clinical trials will enable better design and greater success for patients entering into clinical trials. We are collaborating with several laboratories around Australia to enable increased pre-clinical trial capacity.

Research area
Cancer

Laboratory
Translational Cancer Research Program

Contact
Dr Louise Winteringham