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RESEARCH OVERVIEW

The Iron Metabolism Laboratory investigates the molecular mechanisms in normal iron metabolism and in the development of iron overload disorder hereditary haemochromatosis. We use transgenic murine models of iron overload and tumor cell lines to investigate cellular iron transport using radiolabelled tracers and expression of iron transporters and regulators of iron homeostasis. We have expertise in the area of molecular and cellular biology of iron including cell isolation and culture, iron transport, gene and protein expression, gene knockdown and immunohistochemistry. Our experience in these areas should be useful for participants in the ARC Metals in Medicine Network for the testing or screening of metals or metal complexes in biological systems.

LATEST NEWS

WA leading in $20 million pre-pregnancy genetic carrier screening research

WA is leading the way in a national $20 million pre-pregnancy screening study testing volunteer couples for genetic mutations that cause devastating diseases. The program known as Mackenzie’s Mission, co-led by Harry Perkins Institute of Medical Research geneticist Professor Nigel Laing AO, aims is to test 1300 WA couples by…

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A tennis tournament to celebrate a life and help save others

Ross Sawatzky was the big, gentle straight-talking President of the North Shore Country Club who teammates said was great to play doubles with and even better to play against because he was such a good competitor. The respect in which he was held brought 50 players from 12 clubs in…

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Cancer researcher inspired by nature to kill cancer

A WA discovery made global news when venom from honeybees was found to kill aggressive breast cancer cells. Associate Professor and Wesfarmers Fellow, Dr Pilar Blancafort, from the Harry Perkins Institute of Medical Research, co-published these findings with her PhD student Dr Ciara Duffy and laboratory co-workers a few months…

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