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RESEARCH OVERVIEW

The Iron Metabolism Laboratory investigates the molecular mechanisms in normal iron metabolism and in the development of iron overload disorder hereditary haemochromatosis. We use transgenic murine models of iron overload and tumor cell lines to investigate cellular iron transport using radiolabelled tracers and expression of iron transporters and regulators of iron homeostasis. We have expertise in the area of molecular and cellular biology of iron including cell isolation and culture, iron transport, gene and protein expression, gene knockdown and immunohistochemistry. Our experience in these areas should be useful for participants in the ARC Metals in Medicine Network for the testing or screening of metals or metal complexes in biological systems.

LATEST NEWS

New discovery for treatment of primary liver cancer shows promise

A study using preclinical models has discovered a drug combination with the potential to treat one of the most fatal and globally widespread cancers, a type of primary liver cancer called hepatocellular carcinoma (HCC). The collaborative research team found the drug combination reverses the symptoms of nonalcoholic steatohepatitis (NASH) and,…

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AI stethoscope to help detect early signs of heart disease

New AI stethoscope could revolutionise medicine and help detect the early signs of heart valve disease A digital stethoscope that will easily be able to detect early signs of heart valve disease through the use of sophisticated artificial intelligence algorithms could be available to physicians by the end of this…

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Scientists find way to wipe a cell’s memory to better reprogram it as a stem cell

In a groundbreaking study published today in Nature, Australian scientists have resolved a long-standing problem in regenerative medicine. Led by Professor Ryan Lister from the Harry Perkins Institute of Medical Research and The University of Western Australia and Professor Jose M Polo from Monash University and the University of Adelaide,…

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