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RESEARCH OVERVIEW

The Iron Metabolism Laboratory investigates the molecular mechanisms in normal iron metabolism and in the development of iron overload disorder hereditary haemochromatosis. We use transgenic murine models of iron overload and tumor cell lines to investigate cellular iron transport using radiolabelled tracers and expression of iron transporters and regulators of iron homeostasis. We have expertise in the area of molecular and cellular biology of iron including cell isolation and culture, iron transport, gene and protein expression, gene knockdown and immunohistochemistry. Our experience in these areas should be useful for participants in the ARC Metals in Medicine Network for the testing or screening of metals or metal complexes in biological systems.

LATEST NEWS

Hunt for missing genetics given million-dollar boost

Families from around the world with debilitating inherited diseases will be the beneficiaries of a $1,284,836.30 grant by the Australian federal government to a leading Perth geneticist. Dr Gina Ravenscroft, at the Harry Perkins Institute of Medical Research, will use the National Health and Medical Research Council’s Emerging Leader 2…

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New treatment discovery for rare eye cancer

An unusual and often fatal form of eye melanoma shows early response to new combination of treatments. New discoveries in treatments are all about improved health outcomes for people who have diseases like cancer, and providing them with more time with families.   Thanks to the ongoing support of donors…

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Genetic disease hunt resolved after 20-year search for a gene for facial deformity condition

Published in Nature Communications. International hunt by geneticists in Perth, Australia and Yale University, U.S.A. find cause of significant facial deformity disease   Families with hemifacial microsomia, a condition where one side of the face is underdeveloped and does not grow normally, will for the first time be able to find…

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