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Dr Saman Sargazi

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Senior Post-doctoral Fellow

Dr Saman Sargazi

Chromatin & Ageing

Contact details

[email protected]

Senior Post-doctoral Fellow

Dr Saman Sargazi

Chromatin & Ageing


Profile

Dr. Saman Sargazi is an award-winning Clinical Biochemist with 7+ years of experience advancing precision medicine through translational research. His work bridges clinical biochemistry with molecular and nanoscale technologies to address unmet biomedical needs, with expertise in molecular biology, biomarker discovery and nanobiochemistry. He is also committed to research excellence and team development, having mentored trainees and colleagues while helping streamline experimental workflows and strengthen reproducibility across projects.


He has been recognised as a Top 2% Global Scientist (Elsevier/Stanford, 2023–2025) and has authored 159 peer-reviewed publications with a Scopus H-index of 38, reflecting sustained contributions to high-impact biomedical research.


At the Harry Perkins Institute of Medical Research within the Chromatin & Ageing laboratory, Saman’s current research focuses on the epigenetic mechanisms of ageing. He investigates how chromatin organisation and epigenetic regulation shape cellular identity over time, influence genome function and contribute to age-associated decline. His long-term goal is to translate mechanistic insight into actionable therapeutic strategies – identifying targets and developing approaches that can modulate epigenetic states to promote healthier ageing and support anti-ageing interventions.


Selected Publications

View Dr Sargazi’s Google Scholar profile.

    1. Barani M, Zargari F, Mirinejad S, Madani F, Hajinezhad MR, Sargazi S. Ginsenoside Rg3-encapsulated pegylated niosomes exhibit multimodal therapeutic potential in Alzheimer’s disease. Scientific Reports. 2025 Dec 14. https://www.nature.com/articles/s41598-025-32528-3
    2. Davodabadi F, Nasri N, Valizadeh N, Haji Ali B, Ghotekar S, Sargazi S, Barani M, Rahman MM. Nanotechnology-enhanced delivery systems for bioactive citrus compounds: a comprehensive review. Critical Reviews in Food Science and Nutrition. 2025 Nov 4:1-45. https://www.tandfonline.com/doi/full/10.1080/10408398.2025.2584454
    3. Sargazi S, Mirinejad S, Hajinezhad MR, Madani F, Majidpour M, Barani M. Delivery of GRg3 via alginate/PLGA nanoparticles: physicochemical, cellular, and in vivo biocompatibility assessments. Drug Development and Industrial Pharmacy. 2025 Nov 10:1-7. https://www.tandfonline.com/doi/full/10.1080/03639045.2025.2585400
    4. Poormolaie N, Bohlooli M, Movahedi M, Sargazi S. G-C₃N₅/AuNPs-based electrochemical aptasensor for ultrasensitive doxorubicin detection in human plasma and urine. Microchemical Journal. 2025 Nov 23:116282. https://www.sciencedirect.com/science/article/pii/S0026265X2503632X
    5. Hajinezhad MR, Barani M, Sargazi S. Histopathological and biochemical profiling of Carfilzomib-loaded Fe–Co MOFs. Discover Nano. 2025 Aug 14;20(1):135. https://link.springer.com/article/10.1186/s11671-025-04334-3
    6. Davodabadi F, Sargazi S, Baino F. Recent advances in hydrogel-based drug delivery systems for enhanced cancer therapy: A review. Materials Today Communications. 2025 Aug 19:113615. https://www.sciencedirect.com/science/article/pii/S2352492825021270
    7. Fathi-Karkan S, Davodabadi F, Mirinejad S, Sargazi S, Amri J, Ulucan-Karnak F, Peker HU, Sargazi S. Breaking Barriers in Cancer Treatment: An updated review on Clinical Translation of Novel Nanocarrier Systems. Acta Biochimica Iranica. 2025 Jul 13. https://publish.kne-publishing.com/index.php/ABI/article/view/19103
    8. Hajinezhad MR, Fathi-Karkan S, Roostaee M, Sargazi S, Mirinejad S, Sheervalilou R, Sargazi S, Barani M. Engineering pH-responsive niosomes with ergosterol and CHEMS for controlled carfilzomib release: Insights from in vitro and in vivo studies. Drug Development and Industrial Pharmacy. 2025 Sep 2;51(9):1122-37. https://www.tandfonline.com/doi/full/10.1080/03639045.2025.2530161
    9. Sabeti Akbar-Abad M, Majidpour M, Keykha F, Maleki M, Piroozan Y, Saravani R, Zandhaghighi M, Shahriari H, Sargazi S. Preliminary insight into the potential role of Leptin Receptor Polymorphisms in Type 2 Diabetes Risk: Case-control study and bioinformatics analysis. Journal of Diabetes & Metabolic Disorders. 2025 Jun;24(1):1-2. https://link.springer.com/article/10.1007/s40200-025-01617-5.
    10. Sabeti Akbar-Abad M, Majidpour M, Sargazi S, Ghasemi M, Saravani R. Unraveling the Role of Cathepsin B Variants in Polycystic Ovary Syndrome: Insights from a Case-Control Study and Computational Analyses. Reproductive Sciences. 2025 Mar 5:1-4. https://link.springer.com/article/10.1007/s43032-025-01806-w.
    11. Shokati S, Sargazi S, Majidpour M, Mirinejad S,Naderi G-N Z, Shahraki M, et al. Decoding the Link: Exploring FMO3 Gene Variations as a Key to Understanding Type Two Diabetes Through Bioinformatics and Case–Control Analyses. Indian Journal of Clinical Biochemistry. 2025 Feb. https://link.springer.com/article/10.1007/s12291-024-01295-9
    12. Ghalichi L, Shariat SV, Naserbakht M, Taban M, Abbasi-Kangevari M, Afrashteh F, et al. National and subnational burden of mental disorders in Iran (1990–2019): findings of the global burden of Disease 2019 study. The Lancet Global Health. 2024 Dec 1;12(12):e1984-92. https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(24)00342-5/fulltext
    13. Majidpour M, Sargazi S, Ghasemi M, Sabeti Akbar-Abad M, Sarhadi M, Saravani R. LncRNA MEG3, GAS5, and HOTTIP Polymorphisms Association with Risk of Polycystic Ovary Syndrome: A Case–Control Study and Computational Analyses. Biochemical Genetics. 2024 Nov 29:1-23. https://link.springer.com/article/10.1007/s10528-024-10977-1
    14. Majidpour M, Azizi SG, Davodabadi F, Akbar-Abad MS, Abdollahi Z, Sargazi S, Shahriari H. Recent Advances in TGF-β Signaling Pathway in COVID-19 Pathogenesis: A review. Microbial Pathogenesis. 2024 Dec 17:107236. https://www.sciencedirect.com/science/article/abs/pii/S0882401024007034
    15. Arndt MB, Abate YH, Abbasi-Kangevari M, Abd ElHafeez S, Abdelmasseh M, Abd-Elsalam S, et al. Global, regional, and national progress towards the 2030 global nutrition targets and forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet. 2024 Dec 21;404(10471):2543-83. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01821-X/fulltext
    16. Ghaznavi H, Hajinezhad MR, Hesari Z, Shirvaliloo M, Sargazi S, Shahraki S, et al. Synthesis, characterization, and evaluation of copper-doped zinc oxide nanoparticles anticancer effects: in vitro and in vivo experiments. BMC cancer. 2025 Jan 8;25(1):37. https://link.springer.com/article/10.1186/s12885-024-13398-w
    17. Rakhshanizade N, Sargazi S, Karajibani M, Majidpour M, Karajibani A, Montazerifar F, Ghasemi M. Influence of Suppressor of Cytokine Signaling 1 (SOCS1) Gene Variations on Polycystic Ovary Syndrome. Indian Journal of Clinical Biochemistry. 2024 Jul 10:1-0. https://link.springer.com/article/10.1007/s12291-024-01248-2, Scopus Ranking Q1, Citations= 0
    18. Barwant M, Karande V, Basnet P, Kumar D, Sargazi S, Mirzaei M, Jabir MS, Sanap D, Ghotekar S. Insights into the antioxidant and anticancer properties of novel biologically synthesized NiO/Ni2O3 nanoparticles using Sargassum tenerrimum. Journal of Sol-Gel Science and Technology. 2024 Jun 24:1-2. https://link.springer.com/article/10.1007/s10971-024-06446-1, Scopus Ranking Q2, ISI Ranking Q2, Citations= 0
    19. Majidpour M, Saravani R, Sargazi S, Sargazi S, Harati‐Sadegh M, Khorrami S, Sarhadi M, Alidadi A. A Study on Associations of Long Noncoding RNA HOTAIR Polymorphisms with Genetic Susceptibility to Chronic Kidney Disease. Journal of Clinical Laboratory Analysis. 2024 Jun 1:e25086.  https://onlinelibrary.wiley.com/doi/abs/10.1002/jcla.25086, Scopus Ranking Q1, ISI Ranking Q2, Citations= 0