Ashley Soet is passionate about harnessing cutting-edge molecular techniques to improve treatment outcomes for hepatocellular carcinoma in Western Australia and worldwide. In 2019, Ashley obtained a Bachelor of Philosophy (Hons) degree from the University of Western Australia with a primary major of Biochemistry and Molecular Biology and a secondary major of Microbiology and Immunology.
As of 2022, Ashley is a PhD candidate at the Oncofetal Ecosystem Lab studying the tumour microenvironment of hepatocellular carcinoma using multi-omics. The aims of this research are to uncover novel mechanisms for tumour drug resistance, immune evasion, and metastasis, understand the role of tumour mutational burden in these disease processes, and to characterise the fingerprint of these disease processes in liquid biopsies in the form of circulating tumour DNA.
To study HCC solid tumour samples, Ashley will be using single cell proteo-transcriptomics (CITE-seq) and high resolution spatial proteo-transcriptomics. To study circulating tumour DNA in liquid biopsies, he will be using targeted next generation sequencing. Working as a member of the Australian Liver Cancer Collaborative (LCC), Ashley believes that the application of high-resolution multi-omics will be necessary to enable personalised medicine as an accessible means to defeat cancer.