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RESEARCH OVERVIEW

The Onco-Fetal Ecosystem Laboratory focuses on the triquetra of early development, regeneration, and cancer. We are interested in understanding the developmental origin of cancer by uncovering the similarities between embryogenesis and tumor development. In close association with our clinical collaborators, we study how tumors co-evolve with their microenvironment, especially in the context of tumor initiation and resistance to immunotherapy. To address these questions, we combine single-cell genomics, spatial transcriptomics, and machine learning approaches. We are expanding our collaborations to integrate experimental, computational, and clinical knowledge to exhume the ‘seeds’ of cancer development.

Dr Ankur Sharma

Dr Ankur Sharma

Onco-Fetal Ecosystem

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A new cancer-causing gene and protein which creates highly aggressive hard to treat breast cancers has been discovered by cancer researchers at the Harry Perkins Institute. The discovery has been…

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