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RESEARCH OVERVIEW

One in six Australians has impaired kidney function, with one in three at risk of developing kidney disease.

The Translational Renal Research group in focussed on improving outcomes for patients with renal diseases, by translating advances in basic science from the bench to the bedside.

The main areas of interest for the group are:

  • Host responses to common viruses causing disease after renal transplantation
  • Quantification of immune function through the assessment of recall antigen responses
  • Interactions between bacteria and peritoneal mesothelial cells and the development of peritoneal-dialysis related peritonitis

CURRENT RESEARCH PROJECTS

Project

Project

Project Outline

1. The influence of multistrain cytomegalovirus infections on the immune repertoire: implications for organ transplantation
2. A systematic analysis of interactions between common pathogens causing peritoneal-dialysis associated peritonitis and peritoneal mesothelial cells.
3. The safety and efficacy of intraperitoneal tPA and DNase in the treatment of PD-peritonitis, pre-clinical and phase 1 clinical studies.
4. Analysis of cell free DNA as an early marker of sepsis and endothelial cell function

Research area
Cell Signaling

CURRENT STUDENT PROJECTS

Student Project

Developing novel diagnostics for the earlier detection and treatment of peritonitis

Student Project

Developing novel diagnostics for the earlier detection and treatment of peritonitis

Project Outline

Chief supervisor
Dr Aron Chakera

Project suitable for
Masters, PhD

Student Project

The role of mesothelial cells in peritoneal-dialysis associated peritonitis

Student Project

The role of mesothelial cells in peritoneal-dialysis associated peritonitis

Project Outline

Chief supervisor
Dr Aron Chakera

Project suitable for
PhD

Student Project

Understanding bacterial factors that predict more severe disease

Student Project

Understanding bacterial factors that predict more severe disease

Project Outline

Chief supervisor
Dr Aron Chakera

Project suitable for
PhD

Student Project

Using peritoneal dialysis as a uniquely accessible human system to study host-pathogen interactions linked to standardized clinical outcomes

Student Project

Using peritoneal dialysis as a uniquely accessible human system to study host-pathogen interactions linked to standardized clinical outcomes

Project Outline

Chief supervisor
Dr Aron Chakera

Project suitable for
PhD