New way to examine how medicines act on cells
By leafcutter_admin | Cancer, Chronic Kidney Disease, Disease Area, Lab, Molecular Endocrinology and Pharmacology, Molecular Medicine, News & Events, Research, Research AreaUsing a genome editing technique called CRISPR/Cas9, the researchers attached a super-bright glowing molecule, derived from deep sea shrimp, to specific molecules important for signalling in cancer cells, ‘receptors’. Receptors…
Ground-breaking new study doubles the estimate of our functional genes
By leafcutter_admin | Cancer, Cancer and Cell Biology, Disease Area, Genes, Lab, News & Events, Research, Research Area, Systems Biology and GenomicsThe findings, published in Nature, were the latest work of the FANTOM5 consortium, a group of researchers from Japan and Australia led by Professor Alistair Forrest from the Perkins and The University of…
New method to fight hard to treat breast cancers
By leafcutter_admin | Breast Cancer, Cancer and Cell Biology, Cancer Epigenetics, Disease Area, Lab, News & Events, Research, Research AreaThe research led by Perkins researcher Dr Anabel Sorolla involves the use of nanoparticles to deliver a series of anti-cancer agents directly to the tumour. The study focused on triple…
Sudden infant cardiac death explained by gene mutation
By leafcutter_admin | Lab, Molecular Medicine, Neurogenetic Diseases, News & Events, Research, Research AreaLast year the Perkins Neurogenetic Diseases Laboratory received DNA from a family in Scotland whose four-month-old baby had tragically suffered a cardiac arrest and died. With the family’s permission, their doctor sent…
Perkins researchers turn on cancer killing genes
By leafcutter_admin | Cancer and Cell Biology, Cancer Epigenetics, Disease Area, Lab, News & Events, Research, Research Area, TumoursDr Benjamin Garcia Bloj, along with his labmates from the Perkins Cancer Epigenetics Laboratory headed by Associate Professor Pilar Blancafort, used a gene-editing technology called CRISPR to ‘wake up’ key tumour suppressors to…
Perkins researchers find essential gene for healthy hearts
By leafcutter_admin | Disease Area, Heart, Lab, Mitochondrial Medicine and Biology, Molecular Medicine, News & Events, Research, Research Area, Synthetic Biology and Drug DiscoveryProfessor Aleksandra Filipovska and her team from the Perkins Mitochondrial Medicine and Biology Laboratory in collaboration with Professor Oliver Rackham and Professor Nils Göran Larsson and his team from the Max Planck Institute for Biology…
Perkins researchers decipher world-first muscle disorder cases
By leafcutter_admin | Disease Area, Genes, Lab, Molecular Medicine, Muscles, Neurogenetic Diseases, News & Events, Research, Research AreaDuring their investigation the multi-national team of researchers studied a muscle protein that is strongly influenced by calcium. The protein, known as tropomyosin-3 (TPM3), is vital for skeletal muscle development…
Cause of mitochondrial dysfunction discovered by Perkins researchers
By leafcutter_admin | Disease Area, Lab, Mitochondrial disease, Mitochondrial Medicine and Biology, Molecular Medicine, News & Events, Research, Research AreaThe disease, known as Leigh Syndrome, has previously been linked to a genetic mutation, but Perkins researchers were able to determine how the mutation led to mitochondrial dysfunction. Mitochondria are…